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Formal and consistency checks are done by computer programs, each data set on a classified enzyme is checked manually by at least one biologist and one chemist.

Information on EC 6

In order to keep the tables concise redundant information is avoided as far as possible e. On the other hand the original authors' nomenclature for enzyme forms and subunits is retained as is their nomenclature for organisms and strains even if the organism is reclassified in the meantime.

It should be mentioned here that the data are extracted from literature and critically evaluated by qualified scientists. Search & Highlight Search Pathway ×. Data on enzyme function are extracted directly from the primary literature by scientists holding a degree in Biology or Chemistry.

See terms of use for full details. The enzymes are classified according to the Enzyme Commission list of enzymes. Nevertheless a systematic collection is essential for our interpretation of the genome information and more so for possible applications of this knowledge in the fields of medicine, agriculture, etc.

Before downloading any files from BRENDA, you have to actively accept the license. Latest BRENDA release Release - May 30, Including new and updated enzyme classes. Please make sure you have JavaScript enabled in your browser settings. We're sorry, but BRENDA doesn't work properly without JavaScript.

Those data are inherently very difficult to collect, interpret and standardize as they are highly distributed among journals from different fields and are often subject to experimental conditions. Frequently enzymes with very different properties are included under the same EC number.

Although we intend to give a representative overview on the characteristics and variability of each enzyme the Handbook is not a compendium. Enzymes from different EC numbers are covered. Introduction print. Today, as the large international genome sequence projects are gaining a great amount of public attention and huge sequence data bases are created, it becomes more and more obvious that we are very limited in our ability to access functional data for the gene products - the proteins, in particular for enzymes.

It is available free of charge via the internet (). The reader will have to go to the primary literature for more detailed information. Member of. The data collection is being developed into a metabolic network information system with links to Enzyme expression and regulation information.

Any feedback? It is available free of charge via the internet www. All copyrightable parts of BRENDA are licensed under Creative Commons Attribution License (CC BY ). Naturally it is not possible to cover all the numerous literature references for each enzyme for some enzymes up to if the data representation is to be concise as is intended.

BRENDA - The Comprehensive Enzyme Information SystemFor a more structured view of enzymes/EC Numbers and enhanced search capabilities please go to the EC Explorer. Recent progress on enzyme immobilisation, enzyme production, enzyme inhibition, coenzyme regeneration and enzyme engineering has opened up fascinating new fields for the potential application of enzymes in a large range of different areas.

BRENDA is the main collection of enzyme functional data available to the scientific community.